Blood+ aka Buraddo Purasu, pronounced "Blood Plus," is an anime series produced by Production I.G and Aniplex and directed by Junichi Fujisaku. It is the year 2003, in Okinawa. A high school girl Otonashi Saya spends her life peacefully with her adopted father George and his two adopted sons Kai and Riku. Saya cannot seem to remember anything before one year ago. Will Saya remember about her past? Will the monsters be stopped?